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ETP-46321 Chemical Structure

ETP-46321

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP19935CAS No. ：1252594-99-2Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1252594-99-2 Cat. No. BCP19935
Name ETP-46321
Synonyms ETP46321;ETP 46321;
SMILES
Chemical Name
Formula C20H27N9O3S M. Wt 473.55
Purity 98% Storage Store at 4-8°C
Description ETP-46321, has been pro?led and shown to be a potent PI3K a and d inhibitor, highly selective versus mTOR and 288 representative kinases. The compound demonstrated a good pharmacokinetic profile in mice and was selected for preliminary in vivo evaluation in a lung tumor mouse model driven by a K-Ras G12V oncogenic mutation, showing significant tumor growth inhibition (ca. 51%), and reduction of the tumor metabolic activity as measured by PET techniques.
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