Ro 31-8220

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP13149CAS No. ：125314-64-9Purity：98%

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CAS No.	125314-64-9	Cat. No.	BCP13149
Name	Ro 31-8220
Synonyms	Ro-31-8220;RO31-8220; RO31-8220; RO318220; RO-318220; RO 318220;Bisindolylmaleimide IX;
SMILES
Chemical Name
Formula	C25H23N5O2S	M. Wt	457.55
Purity	98%	Storage	Store at 4-8°C
Description	Ro 31-8220, a staurosporine (sc-3510) analog, is a cell-permeable inhibitor of PKC (protein kinase C) isoforms PKC α, PKC βI, PKC βII, PKC γ, and PKC ε (IC50 = 5, 24, 14, 27, and 24 nM, respectively). Ro 31-8220 has also been shown to induce apoptosis in various cell lines, independent of its PKC activity, and to inhibit GSK 3 (IC50 = 6.8nM). Ro 31-8220 is an inhibitor of Cdk2, cyclin A, GSK-3β, MSK1, Pim-3, Polycystin-1, PRK2, Rsk-1 and Rsk-2 and an activator of JNK1. Ro 31-8220 antagonized (IC50, 1.0 microM) the effect of the activator of protein kinase C,12-O-tetradecanoylphorbol 13-acetate (TPA), on histamine-stimulated aminopyrine accumulation. Ro 31-8220 (0.1-2.14 microM) inhibited the aminopyrine response to 0.1 mM carbachol (IC50, 0.78 microM; 49% inhibition at 2.14 microM Ro 31-8220) and shifted the dose-response curve for the effect of carbachol concentration of aminopyrine accumulation downwards and to the right. No inhibition of aminopyrine accumulation induced by histamine