AMG-511
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1253573-53-3 | Cat. No. | BCP28993 |
| Name | AMG-511 | ||
| Synonyms | AMG 511; AMG511; | ||
| SMILES | NC1=NC(C2=CC([C@H](N3CCN(S(=O)(C)=O)CC3)C)=CN=C2NC4=CC(F)=C(OC)N=C4)=NC(C)=N1 | ||
| Chemical Name | |||
| Formula | C22H28FN9O3S | M. Wt | 517.58 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | AMG-511 is a potent and selective pan class I PI3K inhibitor exhibiting IC50 values of 8, 11, 2, and 6 nM against the PI3K β, α, β, and ≤ isoforms respectively. AMG 511 inhibited PI3K pathway signaling in U87 MG glioblastoma cells as determined by dose-dependent reduction in AKT S473 phosphorylation (IC50 = 4 nM). AKT inhibition resulted in a concomitant reduction in PRAS40 phosphorylation (IC50 = 23 nM), a downstream effector of AKT. Reduced phosphorylation of mTORC1 substrates p70S6K (IC50 = 30 nM) and S6 (IC50 = 70 nM) but not 4EBP1 (T37/46), was also detected in U87 MG cells. | ||
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