AI-10-49
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| CAS No. | 1256094-72-0 | Cat. No. | BCP15184 |
| Name | AI-10-49 | ||
| Synonyms | AI 10-49; AI10-49; AI-1049; AI 1049; AI1049; | ||
| SMILES | FC(F)(F)OC1=CC=C2N=C(C3=NC=C(OCCOCCOC4=CN=C(C5=NC6=CC=C(OC(F)(F)F)C=C6N5)C=C4)C=C3)NC2=C1 | ||
| Chemical Name | |||
| Formula | C30H22F6N6O5 | M. Wt | 660.52 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | AI-10-49 is an inhibitor that binds the transcription factor fusion CBFβ-SMMHC. AI-10-49, that selectively binds to CBFβ-SMMHC and disrupts its binding to RUNX1. AI-10-49 restores RUNX1 transcriptional activity, displays favorable pharmacokinetics, and delays leukemia progression in mice. Treatment of primary inv(16) AML patient blasts with AI-10-49 triggers selective cell death. These data suggest that direct inhibition of the oncogenic CBFβ-SMMHC fusion protein may be an effective therapeutic approach for inv(16) AML, and they provide support for transcription factor targeted therapy in other cancers. | ||
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