Olverembatinib New
Data Sheet
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| CAS No. | 1257628-77-5 | Cat. No. | BCP07502 |
| Name | Olverembatinib | ||
| Synonyms | GZD-824;GZD 824;GZD824;HQP1351;HQP 1351;HQP-1351; | ||
| SMILES | CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CC5=C(NN=C5)N=C4 | ||
| Chemical Name | |||
| Formula | C29H27F3N6O | M. Wt | 532.56 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | GZD-824 is an orally available inhibitor of a broad spectrum of Bcr/Abl tyrosine kinase mutants including T315I (IC50s = 0.34 and 0.68 nM for wild-type Bcr/Abl and Bcr/AblT315I, respectively). It has been shown to suppress the proliferation of Bcr/Abl-positive K562 and Ku812 human chronic myelogenous leukemia cells (IC50s = 0.2 and 0.13 nM, respectively) and induce tumor regression in mouse xenograft tumor models driven by either wild-type or mutant Bcr/Abl. | ||
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