GNF179
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1261114-01-5 | Cat. No. | BCP14707 |
| Name | GNF179 | ||
| Synonyms | GNF-179;GNF 179; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C22H23ClFN5O | M. Wt | 427.9 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | GNF179 exhibits a low clearance (CL=22 ml/min/kg, ~25% of hepatic blood flow in mice), a large volume of distribution (steady-state volume of distribution, Vss=11.8 l/kg), a moderate residence time (MRT=9 hours) and suitable terminal half-life (t1/2=8.9 hours). GNF179 reduced Plasmodium berghei parasitemia levels by 99.7% with a single 100 mg/kg oral dose, and prolonged mouse survival by an average of 19 days. GNF179 was able to protect against an infectious P. berghei sporozoite challenge with a single oral dose at 15 mg/kg while NITD609 was not. | ||
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