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Debio-1347 Chemical Structure

Debio-1347

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP14354CAS No. ：1265229-25-1Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1265229-25-1 Cat. No. BCP14354
Name Debio-1347
Synonyms FF-284;FF 284;FF284;Debio 1347;Debio1347;CH 518328;CH5183284;CH-5183284;
SMILES O=C(C1=C(N)N(C2=CC=C3N=C(C)NC3=C2)N=C1)C(N4)=CC5=C4C=CC=C5
Chemical Name
Formula C20H16N6O M. Wt 356.38
Purity 98% Storage Store at 4-8°C
Description Debio-1347, also known as FF284 and CH5183284, is an orally bioavailable inhibitor of the fibroblast growth factor receptor subtypes 1 (FGFR-1), 2 (FGFR-2) and 3 (FGFR-3), with potential antineoplastic activity. FGFR inhibitor debio 1347 binds to and inhibits FGFR-1, -2, and -3, which result in the inhibition of FGFR-mediated signal transduction pathways. This leads to the inhibition of both tumor cell proliferation and angiogenesis, and causes cell death in FGFR-overexpressing tumor cells.
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