INK1117

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP09230CAS No. ：1268454-23-4Purity：98%

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CAS No.	1268454-23-4	Cat. No.	BCP09230
Name	INK1117
Synonyms	MLN1117;MLN-1117;MLN 1117;INK-1117;INK 1117;
SMILES
Chemical Name
Formula	C19H17N506	M. Wt	363.37
Purity	98%	Storage	Store at 4-8°C
Description	MLN1117, also known as INK1117, is an orally bioavailable inhibitor of the class I phosphoinositide 3-kinase (PI3K) alpha isoform with potential antineoplastic activity. PI3K alpha inhibitor INK1117 selectively inhibits PI3K alpha kinase, including mutations of PIK3CA, in the PI3K/Akt/mTOR pathway, which may result in tumor cell apoptosis and growth inhibition in PI3K alpha-expressing tumor cells. By specifically targeting class I PI3K alpha, this agent may be more efficacious and less toxic than pan-PI3K inhibitors. Dysregulation of the PI3K/Akt/mTOR pathway is frequently found in solid tumors and results in promoting tumor cell growth, survival, and resistance to chemotherapy and radiotherapy; PIK3CA, one of the most highly mutated oncogenes, encodes the p110-alpha catalytic subunit of the class I PI3K.