(+)-JQ-1
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1268524-70-4 | Cat. No. | BCP07004 |
| Name | (+)-JQ-1 | ||
| Synonyms | (+)-JQ1; (+)-JQ-1; (+)-JQ 1; Bromodomain Inhibitor;JQ-1;JQ1;JQ 1; | ||
| SMILES | CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)OC(C)(C)C)C4=CC=C(C=C4)Cl)C | ||
| Chemical Name | |||
| Formula | C23H25ClN4O2S | M. Wt | 456.99 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | (+)-JQ1 is a potent and highly specific inhibitor for the BET (bromodomain and extra-terminal) family of bromodomains. (+)-JQ1 binds to BRD4 bromodomains 1 and 2 with Kd values of ~ 50 and 90 nM, respectively. The binding is competitive with acetyl lysine. (+)-JQ1 can be a useful chemical probe to investigate the role of BET bromodomains in the transcriptional regulation of oncogenesis. JQ1 exhibited strong dose-and time- dependent inhibition of BRDT and could significantly diminish the activ | ||
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