Pazufloxacin
Data Sheet
For research use only. Not for human use.
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| CAS No. | 127045-41-4 | Cat. No. | BCP12954 |
| Name | Pazufloxacin | ||
| Synonyms | T-3761;T3761;T 3761; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C16H15FN2O4 | M. Wt | 318.3 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Pazufloxacin (T-3761), a new quinolone derivative, showed broad and potent antibacterial activity. T-3761 showed good efficacy in mice against systemic, pulmonary, and urinary tract infections with gram-positive and gram-negative bacteria, including quinolone-resistant Serratia marcescens and Pseudomonas aeruginosa. The in vivo activity of T-3761 was comparable to or greater than those of ofloxacin, ciprofloxacin, norfloxacin, and tosufloxacin against most infection models in mice. The activities of T-3761 were lower than those of tosufloxacin against gram-positive bacterial systemic and pulmonary infections in mice but not against infections with methicillin-resistant Staphylococcus aureus. T-3761 had a broad spectrum of activity and had potent activity against gram-positive and -negative bacteria. The MICs of T-3761 against 90% of the methicillin-susceptible Staphylococcus aureus, methicillin-susceptible and -resistant Staphylococcus epidermidis, and Clostridium spp. tested were 0.39 | ||
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