MI-2

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP11053CAS No. ：1271738-62-5Purity：98%

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CAS No.	1271738-62-5	Cat. No.	BCP11053
Name	MI-2
Synonyms	Menin-MLL inhibitor 2；MI 2；MI2;
SMILES
Chemical Name
Formula	C18H25N5S2	M. Wt	375.5
Purity	98%	Storage	Store at 4-8°C
Description	in vitro: The menin-MLL inhibitors very effectively blocked proliferation of MLL-AF9 and MLL-ENL transduced BMC, with GI50 values of about 5 μM for MI-2 and MI-3. MI-2 and MI-3 showed only a small effect on the cell growth of E2A-HLF transduced BMC (GI50 > 50 μM). MI-2 and MI-3 substantially and specifically reduce the immortalization potential of cells transformed with MLL fusion oncoproteins [1]. in vivo: MLL-AF9 transformed BMC that remained viable after 7 days of treatment with MI-2 and MI-3 showed substantial changes in morphology, indicative of monocytic differentiation, as evidenced by increased cell size, lower nuclear to cytoplasmic ratio and highly vacuolated cytoplasm. Consistent with the change in cell morphology, the expression of CD11b was substantially increased on MLL-AF9 transformed BMC after 7 days of treatment with MI-2 and MI-3 .