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PF-4989216 Chemical Structure

PF-4989216

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP15976CAS No. ：1276553-09-3Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1276553-09-3 Cat. No. BCP15976
Name PF-4989216
Synonyms PF4989216;PF 4989216;
SMILES
Chemical Name
Formula C18H13FN6OS M. Wt 380.4
Purity 98% Storage Store at 4-8°C
Description PF-4989216 is a potent and selective PI3K inhibitor with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM for p110α, p110β, p110γ, p110δ, and VPS34, respectively. PF-4989216 is a novel potent and selective PI3K inhibitor. PF-4989216 inhibits the phosphorylation of PI3K downstream molecules and subsequently leads to inhibition in cell proliferation and xenograft tumor growth in NSCLCs harboring a PIK3CA mutation, including an erlotinib resistant line, NCI-H1975. PF-4989216 inhibited PI3K downstream signaling and subsequently led to apoptosis induction, and inhibition in cell viability, transformation, and xenograft tumor growth in SCLCs harboring PIK3CA mutation.
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