ML-167
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1285702-20-6 | Cat. No. | BCP08599 |
| Name | ML-167 | ||
| Synonyms | ML167;ML167; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C19H17N3O3 | M. Wt | 335.36 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | ML167 is the first highly selective inhibitor of of Cdc2-like kinase 4 (Clk4) with an IC50 of 136 nM for Clk4, >10-fold selectivity for closely related kinases Clk1-3 and Dyrk1A/1B, and minimal activity against a panel of other kinases tested. The Cdc2-like kinases (Clk’s) and the dual-specificity tyrosine phosphorylation-regulated kinases (Dyrk’s) are involved in regulation of gene splicing. The Cdc2-like kinases phosphorylate the serine/arginine-rich (SR) proteins, a major component of the spliceosome. | ||
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