I-BET151
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1300031-49-5 | Cat. No. | BCP03612 |
| Name | I-BET151 | ||
| Synonyms | IBET151;GSK1210151A;I-BET 151;GSK-1210151A;GSK 1210151A; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C23H21N5O3 | M. Wt | 415.44 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | I-BET151 induces apoptosis and G0/G1 cell cycle arrest in MLL-fusion leukemic cell lines in vitro (IC50 values are 15, 26, 120 and 192 nM for NOMO1, MV4;11, MOLM13 and RS4;11 cell lines respectively). I-BET151 reduces BCL2 expression in NOMO1 cells. I-BET151 improves survival in two rodents models of MLL-fusion leukemia in vivo. | ||
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