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Lomustine Chemical Structure

Lomustine

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP06551CAS No. ：13010-47-4Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 13010-47-4 Cat. No. BCP06551
Name Lomustine
Synonyms 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea1-(2-chloroethyl)-3-cyclohexyl-1-nitroso-urea13010-47-4NCI60_0417431-(2-Chloroethyl)-3-cyclohexylnitrosourea1-Nitrosourea, 1-(2-chloroethyl)-3-cyclohexyl-Be;
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Chemical Name
Formula C9H16ClN3O2 M. Wt 233.6973
Purity 98% Storage Store at 4-8°C
Description Lomustine inhibits the growth of ZR-75-1 and U373 with IC50 of 12 μM and 15 μM, respectively. Lomustine reduces the level of expression of the DNA repair protein O6-alkylguanine-DNA alkyltransferase.Lomustine (420 μM) triggers apoptosis through the mitochondrial pathway via decrease in the level of the anti-apoptosis proteins Bcl-2 and Bcl-xl, respectively, in both medulloblastoma and normal human epithelial and fibroblast cells. Lomustine induces cell cycle delay in G2/M phase in medulloblastoma cells and up-regulates p21 protein level in a p53-independent manner in HFSN1 cells.
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