Sulfatinib
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1308672-74-3 | Cat. No. | BCP14757 |
| Name | Sulfatinib | ||
| Synonyms | HMPL012; HMPL012; HMPL 012; surufatinib; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C24H28N6O3S | M. Wt | 480.58 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Sulfatinib is an orally bioavailable, small molecule inhibitor of vascular endothelial growth factor receptors (VEGFR) 1, 2, and 3, and the fibroblast growth factor receptor type 1 (FGFR1), with potential antineoplastic and anti-angiogenic activities. Upon oral administration, sulfatinib binds to and inhibits VEGFRs and FGFR1 thereby inhibiting VEGFR- and FGFR1-mediated signal transduction pathways. This leads to a reduction of angiogenesis and tumor cell proliferation in VEGFR/FGFR1-overexpressing tumor cells. Expression of VEGFRs and FGFR1 may be upregulated in a variety of tumor cell types. | ||
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