Tubastatin A hydrochloride
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CAS No. | 1310693-92-5 | Cat. No. | BCP02887 |
Name | Tubastatin A hydrochloride | ||
Synonyms | Tubastatin A HCl;TSA HCl; | ||
SMILES | |||
Chemical Name | |||
Formula | C20H21N3O2.HCl | M. Wt | 371.86 |
Purity | 98% | Storage | Store at 4-8°C |
Description | Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM. Comparatively, it demonstrates over 1,000-fold selectivity against all other HDAC isoforms (IC50s >16 μM), excluding HDAC8 (IC50 = 0.9 μM). Tubastatin A induces α-tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures. In a model of oxidative stress induced by glutathione depletion, tubastatin A displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 μM. |
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