NVP-CGM097
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1313363-54-0 | Cat. No. | BCP18308 |
| Name | NVP-CGM097 | ||
| Synonyms | CGM097;CGM 097;CGM-097;NVP CGM097; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C38H47ClN4O4 | M. Wt | 659.26 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Upon oral administration, p53/HDM2 interaction inhibitor CGM097 inhibits the binding of the HDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this HDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited, which may result in the restoration of p53 signaling and, thus, the p53-mediated induction of tumor cell apoptosis. HDM2, a zinc finger nuclear phosphoprotein, is a negative regulator of the p53 pathway, often overexpressed in cancer cells and has been implicated in cancer cell proliferation and survival. | ||
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