Citarinostat
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1316215-12-9 | Cat. No. | BCP09545 |
| Name | Citarinostat | ||
| Synonyms | ACY-241; ACY 241; ACY241; HDAC-IN-2; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C24H26ClN5O3 | M. Wt | 467.95 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Citarinostat, also known as ACY-241, is a potent, selective and orally available histone deacetylase (HDAC) inhibitor, with potential antineoplastic activity. Upon oral administration, ACY-241 inhibits the activity of HDACs; this results in an accumulation of highly acetylated chromatin histones, the induction of chromatin remodeling and an altered pattern of gene expression. This leads to the inhibition of tumor oncogene transcription, and the selective transcription of tumor suppressor genes, which inhibit tumor cell division and induce tumor cell apoptosis. | ||
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