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GLPG0187 Chemical Structure

GLPG0187

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP19642CAS No. ：1320346-97-1Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1320346-97-1 Cat. No. BCP19642
Name GLPG0187
Synonyms GLPG-0187;GLPG 0187;
SMILES
Chemical Name
Formula C29H37N7O5S M. Wt 595.71
Purity 98% Storage Store at 4-8°C
Description GLPG0187 is a small molecule integrin receptor antagonist (IRA) with potential antineoplastic activity. Upon administration, GLPG0187 binds to and blocks the activity of 5 RGD-integrin receptor subtypes, including alphavbeta1, alphavbeta3, alphavbeta5, alphavbeta6 and alpha5beta1. This may result in the inhibition of endothelial cell-cell interactions and endothelial cell-matrix interactions, and the prevention of angiogenesis and metastasis in tumor cells expressing these integrin receptors. Integrin receptors are transmembrane glycoproteins expressed on the surface of tumor vessel endothelial cells and some types of cancer cells, and play a crucial role in endothelial cell adhesion and migration.
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