Olanzapine
Data Sheet
For research use only. Not for human use.
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| CAS No. | 132539-06-1 | Cat. No. | BCP04917 |
| Name | Olanzapine | ||
| Synonyms | |||
| SMILES | |||
| Chemical Name | |||
| Formula | C17H20N4S | M. Wt | |
| Purity | Storage | Store at 4-8°C | |
| Description | Olanzapine is an antipsychotic, thienobenzodiazepine compound that has been approved for use in the treatment of schizophrenia and bipolar disorder. Olanzapine binds as an antagonist/inverse agonist to dopamine D1 (Ki = 31 nM), dopamine D2 (Ki = 11 nM), dopamine D4 (Ki = 27 nM), serotonin 5-HT2A (Ki = 4 nM), serotonin 5-HT2C (Ki = 11 nM), serotonin 5-HT3 (Ki = 57 nM), muscarinic M1 (Ki = 2 nM), α1-adrenergic (Ki = 19 nM), and histamine H1 (Ki = 7 nM) receptors.1 Olanzapine has a high affinity for dopamine D1 and D2 receptors (IC50s = 25 and 10 nM, respectively) in human striatal tissue and for 5-HT2A, 5-HT2C, muscarinic M1, and α1-adrenergic receptors (IC50s = 7, 71, 2, and 70 nM, respectively) in human frontal cortex.1 This product is intended for research purposes only. | ||
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