AG-490 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 133550-30-8 | Cat. No. | BCP01722 |
| Name | AG-490 | ||
| Synonyms | AG 490;Tyrphostin B42;AG490;Tyrphostin AG490; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C17H14N2O3 | M. Wt | 294.3 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | AG490 is a JAK-2 specific inhibitor, which inhibits phosphorylation of EGFR and signal transducer and activator of transcription 3 [STAT-3], and subsequently reduce invasion and adhesion potential of malignant cells. The hematopoietic cancer c-Kit+, Jak-2+ and non hematopoietic tumors c-Kit+, HER-2+, JAK-2+ can be inhibited by the chemosensitizing agent AG490 causing programmed cell death. | ||
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