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Pagoclone Chemical Structure

Pagoclone

Data Sheet For research use only. Not for human use.
Cat. No. :BCP28850CAS No. :133737-32-3Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 133737-32-3 Cat. No. BCP28850
Name Pagoclone
Synonyms (+)-RP-59037;CI-1043; IP-456; RP-62955; RP-59037; CI1043; IP456; RP62955; RP59037. Bextra;
SMILES
Chemical Name
Formula C23H22ClN3O2 M. Wt 407.9
Purity 98% Storage Store at 4-8°C
Description Pagoclone, also known as CI-1043; IP-456; RP-62955; RP-59037, is a GABA receptor agonist potentially for the treatment of stuttering, panic disorder and generalised anxiety. It binds with roughly equivalent high affinity (0.7–9.1 nM) to the benzodiazepine binding site of human GABAA receptors containing either an α1, α2, α3 or α5 subunit. It is a partial agonist at α1-, α2- and α5-containing GABAA receptors and a full agonist at receptors containing an α3 subunit.
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