GSK2656157
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CAS No. | 1337532-29-2 | Cat. No. | BCP09007 |
Name | GSK2656157 | ||
Synonyms | GSK 2656157; GSK-2656157; | ||
SMILES | |||
Chemical Name | |||
Formula | C23H21FN6O | M. Wt | 416.45 |
Purity | 98% | Storage | Store at 4-8°C |
Description | GSK2656157 is is highly selective for PERK with IC50 values >100 nM against a panel of 300 kinases. GSK2656157 inhibits PERK activity in cells with an IC50 in the range of 10-30 nM by inhibition of stress-induced PERK autophosphorylation, eIF2α substrate phosphorylation, together with corresponding decreases in ATF4 and CHOP proteins in multiple cell lines. |
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