OTS964(free base) New
Data Sheet
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| CAS No. | 1338540-81-0 | Cat. No. | BCP17413 |
| Name | OTS964(free base) | ||
| Synonyms | OTS-964(free base);OTS 964(free base); | ||
| SMILES | CC(CN(C)C)C1=CC=C(C=C1)C2=C(C=CC3=C2C4=C(C(=O)N3)SC=C4)O | ||
| Chemical Name | |||
| Formula | C23H24N2O2S | M. Wt | 392.52 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | OTS964 is a potent and selective TOPK inhibitor with potential anticancer activity. OTS964 inhibits TOPK kinase activity with high affinity and selectivity. Similar to the knockdown effect of TOPK small interfering RNAs (siRNAs), this inhibitor causes a cytokinesis defect and the subsequent apoptosis of cancer cells in vitro as well as in xenograft models of human lung cancer. Although administration of the free compound induced hematopoietic adverse reactions (leukocytopenia associated with thrombocytosis), the drug delivered in a liposomal formulation effectively caused complete regression of transplanted tumors without showing any adverse reactions in mice. | ||
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