TP-0903
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1341200-45-0 | Cat. No. | BCP15884 |
| Name | TP-0903 | ||
| Synonyms | TP 0903;TP0903; Dubermatinib; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C24H30ClN7O2S | M. Wt | 516.06 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | TP-0903 is a potent and selective AXL inhibitor. TP-0903 induces massive apoptosis in CLL B cells with LD50 values of nanomolar ranges. Combination of TP-0903 with BTK inhibitors augments CLL B-cell apoptosis AXL overexpression is a reoccurring theme observed in multiple tumor types that have acquired resistance to various agents. Treatment of cancer cells with TP-0903 reverses the mesenchymal phenotype in multiple models and sensitizes cancer cells to treatment with other targeted agents. Administration of TP-0903 either as a single agent or in combination with BTK inhibitors may be effective in treating patients with CLL. | ||
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