Tolcapone New
Data Sheet
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| CAS No. | 134308-13-7 | Cat. No. | BCP09156 |
| Name | Tolcapone | ||
| Synonyms | Tasmar;Ro 40-7592;SOM0226;Ro-40-7592;Ro 40 7592;Ro 407592;Ro407592; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C14H11NO5 | M. Wt | 273.24 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Tolcapone is a benzophenone derivative and a catechol-O-methyltransferase (COMT) inhibitor. Tolcapone selectively and reversibly inhibits COMT, an enzyme that catalyzes the metabolism of biologically active catechols and their hydroxylated metabolites by transferring the methyl group of S-adenosyl-L-methionine to the phenolic group of catechol-containing substrates. When given in conjunction with a peripheral dopa decarboxylase inhibitor and levodopa, tolcapone may prevent the metabolism of levodopa to 3-methoxy-4-hydroxy- L-phenylalanine (3-OMD) in the brain and peripheral tissues leading to increased bioavailability and enhancement of delivery to the central nervous system (CNS) of levodopa. | ||
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