GSK343
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1346704-33-3 | Cat. No. | BCP07777 |
| Name | GSK343 | ||
| Synonyms | GSK 343; GSK-343; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C31H39N7O2 | M. Wt | 541.69 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | GSK343 is a specific inhibitor of EZH2 methyltransferase, which can decrease the level of H3K27Me3, the product of EZH2's enzymatic activity. in vitro: GSK343 exhibited limited effects on the growth of EOC cells in conventional two-dimensional (2D) culture. In contrast, GSK343 significantly suppressed the growth of EOC cells cultured in 3D matrigel extracellular matrix (ECM), which more closely mimics the tumor microenvironment. Notably, GSK343 induces apoptosis of EOC cells in 3D but not 2D cu | ||
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