Lamivudine

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP06203CAS No. ：134678-17-4Purity：98%

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CAS No.	134678-17-4	Cat. No.	BCP06203
Name	Lamivudine
Synonyms	Epivir;
SMILES
Chemical Name
Formula	C8H11N3O3S	M. Wt	229.26
Purity	98%	Storage	Store at 4-8°C
Description	Lamivudine is a reverse transcriptase inhibitor and zalcitabine analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat Human Immunodeficiency Virus Type 1 (HIV-1) and hepatitis B (HBV). Lamivudine can inhibit virus replication rapidly and improveliver function, prevent exacerbation in patients with advanced schistosomiasis with chronic B hepatitis. IC50 value of lamivudine on B. adolescentis was 200 microg x mL(-1), and the IC50 values of lamivudine on S. dysenteriae and E. coli were higher than 3 000 microg x mL(-1) and 6 000 microg x mL(1), respectively. Therefore, lamivudine made different inhibitory effects on the three bacteria, in which the B. adolescentis was most susceptible to lamivudine. This work showed that taking lamivudine chronically is likely to affect the balance of good flora in the intestinal tract, and might increase endotoxin release, leading to inflammation and disease progression in hepatopathy .