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ONO-4059 Chemical Structure

ONO-4059

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP18777CAS No. ：1351636-18-4Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1351636-18-4 Cat. No. BCP18777
Name ONO-4059
Synonyms ONO4059;ONO 4059;GS4059;GS-4059;GS 4059;
SMILES
Chemical Name
Formula C25H22N6O3 M. Wt 454.48
Purity 98% Storage Store at 4-8°C
Description In vitro: The compound covalently bonds to BTK, inhibiting BCR signaling and B-cell proliferation and activation. NO/GS-4059 induced durable responses in relapsed/refractory B-cell malignancies without significant toxicities. In vivo: ONO-4059 demonstrated therapeutic efficacy in a mouse arthritis model, and based on its anti-proliferative activity in B-cells.
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