Poseltinib

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP29076CAS No. ：1353562-97-2Purity：98%

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CAS No.	1353562-97-2	Cat. No.	BCP29076
Name	Poseltinib
Synonyms	HM 71224; HM-71224; HM71224; LY 3337641; LY3337641; LY-3337641;
SMILES
Chemical Name
Formula	C26H26N6O3	M. Wt	470.533
Purity	98%	Storage	Store at 4-8°C
Description	Poseltinib, also known HM-71224 and LY3337641, is a tyrosine kinase inhibitor. Poseltinib is an experimental Bruton's tyrosine kinase inhibitor for the treatment of rheumatoid arthritis. HM71224 irreversibly bound to and inhibited Btk (IC50 = 1.95 nM). The compound also inhibited the phosphorylation of Btk and its downstream molecules such as PLCγ2, in activated Ramos B lymphoma cells and primary human B cells in a dose-dependent manner. Furthermore, HM71224 effectively inhibited the production of tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1β by human monocytes, and osteoclast formation by human monocytes. HM71224 inhibits Btk in B cells and monocytes and ameliorates experimental arthritis in a mouse model. HM71224 is a potential novel therapeutic agent for rheumatoid arthritis in humans.