Lobaplatin New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 135558-11-1 | Cat. No. | BCP18138 |
| Name | Lobaplatin | ||
| Synonyms | D19466; D-19466; D 19466; | ||
| SMILES | CC([O-]1)C([O-][Pt]21[NH2+]CC(CC3)C3C[NH2+]2)=O | ||
| Chemical Name | |||
| Formula | C9H18N2O3Pt | M. Wt | 397.33 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Lobaplatin (D-19466) is a diastereometric mixture of platinum(II) complexes containing a 1,2-bis(aminomethyl)cyclobutane stable ligand and lactic acid as the leaving group. Its antitumour activity results from the formation of DNA-drug adducts, mainly as GG and AG intra-strand cross-links. Lobaplatin influences the expression of the c-myc gene, which is involved in oncogenesis, apoptosis and cell proliferation. Lobaplatin has activity in a wide range of preclinical tumour models and appears to overcome tumour resistance to cisplatin and carboplatin in some of these models. In the body, lobaplatin remains largely intact until removed by glomerular filtration. | ||
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