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Palonosetron HCl Chemical Structure

Palonosetron HCl

Data Sheet For research use only. Not for human use.
Cat. No. :BCP06204CAS No. :135729-62-3Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 135729-62-3 Cat. No. BCP06204
Name Palonosetron HCl
Synonyms Aloxi;Onicit;RS-25259-197;
SMILES
Chemical Name
Formula C19H25ClN2O M. Wt 332.87
Purity 98% Storage Store at 4-8°C
Description Palonosetron is a highly potent, selective, second-generation 5-HT3 receptor antagonist with a 5-HT3 receptor binding affinity that is ~100-fold higher than other 5-HT3 receptor antagonists (pKi 10.5 compared with 8.91 for granisetron, 8.81 for tropisetron, 8.39 for ondansetron, 7.6 for dolasetron). Palonosetron also has an extended plasma elimination half-life of ~40 h, significantly longer than others in its class (ondansetron, 4 h; tropisetron, 7.3 h; dolasetron, 7.5 h; ranisetron, 8.9 h).
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