INNO206

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP07265CAS No. ：1361644-26-9Purity：98%

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CAS No.	1361644-26-9	Cat. No.	BCP07265
Name	INNO206
Synonyms	DOXO-EMCH； EMCH-Doxo; EMCH-doxorubicin;INNO-206;INNO 206; Aldoxorubicin;
SMILES
Chemical Name
Formula	C37H42N4O13	M. Wt	750.75
Purity	98%	Storage	Store at 4-8°C
Description	Aldoxorubicin, also known as INNO-206 and Doxo-EMCH, is the 6-maleimidocaproyl hydrazone derivative prodrug of the anthracycline antibiotic doxorubicin with antineoplastic activity. INNO-206 binds selectively to the cysteine-34 position of albumin via its maleimide moiety. Doxorubicin is released from the albumin carrier after cleavage of the acid-sensitive hydrazone linker within the acidic environment of tumors and, once located intracellularly, intercalates DNA, inhibits DNA synthesis, and induces apoptosis. Albumin tends to accumulate in solid tumors as a result of high metabolic turnover, rapid angiogenesis, hyervasculature, and impaired lymphatic drainage. Because of passive accumulation within tumors, this agent may improve the therapeutic effects of doxorubicin while minimizing systemic toxicity.