E7046
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1369489-71-3 | Cat. No. | BCP25989 |
| Name | E7046 | ||
| Synonyms | E-7046; E 7046; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C22H18F5N3O4 | M. Wt | 483.39 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | E7046 is a potent and selective antagonist of the type 4 prostaglandin E2 (PGE2) receptor EP4. EP4 Antagonism by E7046 diminishes Myeloid immunosuppression and synergizes with Treg-reducing IL-2-Diphtheria toxin fusion protein in restoring anti-tumor immunity. E7046 has specific and potent inhibitory activity on PGE2-mediated pro-tumor myeloid cell differentiation and activation. E7046 treatment reduced the growth or even rejected established tumors in vivo in a manner dependent on both myeloid and CD8+ T cells. | ||
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