Pimecrolimus New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 137071-32-0 | Cat. No. | BCP01403 |
| Name | Pimecrolimus | ||
| Synonyms | ASM-981; ASM981; ASM 981; SDZ ASM 981; SDZ-ASM 981; SDZ-ASM-981; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C43H68ClNO11 | M. Wt | 810.45 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Pimecrolimus blocks T-lymphocyte activation pathway by inhibiting calcineurin function.Pimecrolimus prevents the release of cytokines and pro-inflammatory mediators from mast cells. Pimecrolimus binds to macrophilin-12, the pimecrolimusmacrophilin complex then binds to the cytosolic enzyme calcineurin phosphatase. The pimecrolimus-macrophilin complex prevents the dephosphorylation of the cytoplasmic component of the nuclear factor of activated T cells by inhibiting the action of calcineurin. Pimecrolimus inhibits not only the transcription and synthesis of cytokines from mast cells, but also the release of preformed mediators serotonin and β-hexosaminidase by the inhibition of Fc∈-RI-mediated degranulation and secretion. Pimecrolimus treatment causes a strong down-regulation of the expression of mRNA for genes associated with the macrolactam target pathway and inflammation. | ||
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