GSK-J4 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1373423-53-0 | Cat. No. | BCP08261 |
| Name | GSK-J4 | ||
| Synonyms | GSKJ4;GSK J4; GSK-J-4; GSK-J 4; | ||
| SMILES | CCOC(=O)CCNC1=CC(=NC(=N1)C2=CC=CC=N2)N3CCC4=CC=CC=C4CC3 | ||
| Chemical Name | |||
| Formula | C24H27N5O2 | M. Wt | 417.5 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | GSK-J4 is a cell permeable, potent and selective histone demethylase. GSK-J4 is a prodrug of GSK J1, which is the first selective inhibitor of the H3K27 histone demethylase JMJD3 and UTX with IC50 of 60 nM in a cell-free assay and inactive against a panel of demethylases of the JMJ family. GSK-J4 is used to probe the consequences of demethylation of H3K27me3. GSK-J4 inhibits the lipopolysaccharide-induced production of cytokines, including pro-inflammatory tumour necrosis factor (TNF). | ||
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