PBTZ169
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1377239-83-2 | Cat. No. | BCP18094 |
| Name | PBTZ169 | ||
| Synonyms | PBTZ-169;PBTZ 169;Macozinone; | ||
| SMILES | O=C1C2=CC(C(F)(F)F)=CC([N+]([O-])=O)=C2SC(N3CCN(CC4CCCCC4)CC3)=N1 | ||
| Chemical Name | |||
| Formula | C20H23F3N4O3S | M. Wt | 456.48 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | PBTZ169 is a new drug candidate that inhibits decaprenyl-phosphoribose-epimerase (DprE1), an essential enzyme involved in the cell wall biosynthesis of Corynebacterineae. The MIC values of PBTZ169 ranged from 0.03 μg/mL to 0.0037 μg/mL. The MIC50 and MIC90 values of PBTZ169 were 0.0075 and 0.030 μg/mL, respectively. The MIC for PBTZ169 for N. brasiliensis HUJEG-1 was 0.0037 μg/mL. The MICs of SXT, DA-7218, and BTZ043 for this strain were 9.5/0.5, 8, and 0.125 μg/mL, respectively. | ||
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