Pinometostat
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1380288-87-8 | Cat. No. | BCP07426 |
| Name | Pinometostat | ||
| Synonyms | EPZ-5676; EPZ 5676;EPZ5676; | ||
| SMILES | CC(C)N(CC1C(C(C(O1)N2C=NC3=C2N=CN=C3N)O)O)C4CC(C4)CCC5=NC6=C(N5)C=C(C=C6)C(C)(C)C | ||
| Chemical Name | |||
| Formula | C30H42N8O3 | M. Wt | 562.71 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Pinometostat, also known as EPZ-5676, is a small molecule inhibitor of histone methyltransferase with potential antineoplastic activity. Upon intravenous administration, EPZ-5676 specifically blocks the activity of the histone lysine-methyltransferase DOT1L, thereby inhibiting the methylation of nucleosomal histone H3 on lysine 79 (H3K79) that is bound to the mixed lineage leukemia (MLL) fusion protein which targets genes and blocks the expression of leukemogenic genes. | ||
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