EHOP-016
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1380432-32-5 | Cat. No. | BCP09978 |
| Name | EHOP-016 | ||
| Synonyms | EHOP 016;EHOP016; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C25H30N6O | M. Wt | 430.55 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Rac inhibition by EHop-016 increases the activity of the closely related Rho GTPase RhoA by a compensatory mechanism. In MDA-MB-435 cells, EHop-016 (2-5 μM) inhibits association of active Vav2 with Rac1(G15A) mutant fusion protein, and reduces Rac-regulated cell functions including lamellipodia formation and cell migration. In addition, EHop-016 inhibits cell viability of MDA-MB-435 cells with IC50 of 10 μM.EHop-016 also inhibits KITD814V-induced growth in SM and AML patients-derived cells. | ||
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