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GDC-0084 Chemical Structure

GDC-0084

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP18386CAS No. ：1382979-44-3Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1382979-44-3 Cat. No. BCP18386
Name GDC-0084
Synonyms GDC 0084;GDC0084;RG7666;RG-7666;RG 7666;Paxalisib;
SMILES CC1(C2=NC3=C(N2CCO1)N=C(N=C3N4CCOCC4)C5=CN=C(N=C5)N)C
Chemical Name
Formula C18H22N8O2 M. Wt 382.42
Purity 98% Storage Store at 4-8°C
Description Paxalisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. paxalisib specifically inhibits PI3K in the PI3K/AKT kinase (or protein kinase B) signaling pathway, thereby inhibiting the activation of the PI3K signaling pathway. This may result in the inhibition of both cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis. Dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents.
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