Capsazepine

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP12782CAS No. ：138977-28-3Purity：98%

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CAS No.	138977-28-3	Cat. No.	BCP12782
Name	Capsazepine
Synonyms
SMILES
Chemical Name
Formula	C19H21ClN2O2S	M. Wt	376.9
Purity	98%	Storage	Store at 4-8°C
Description	Capsazepine blocks the painful sensation of heat caused by capsaicin which activates the TRPV1 ion channel. in vitro: Capsazepine potentiated the effect of TRAIL, as shown by its effect on intracellular esterase activity; activation of caspase-8,-9, and -3; and colony-formation assay. Capsazepine induced death receptors (DRs) DR5 and DR4, but not decoy receptors, at the transcriptional level and in a non-cell-type-specific manner . Capsazepine (10 microM) reversibly reduced or abolished the current response to capsaicin (500 nM) of voltage-clamped dorsal root ganglion (DRG) neurones from rats. in vivo: Capsazepine (1-100 microM, 45 min preincubation) inhibited the evoked CGRP-LI release. Capsaicin-induced release was significantly inhibited by 77, 92 and 96% with 10, 30 and 100 microM capsazepine, respectively. Low pH-induced release was inhibited by 78, 84, 88 and 93% with 3, 10, 30 and 100 microM capsazepine, respectively. KCl-induced release was significantly inhibited by 55 and 93%