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Lys05 Chemical Structure

Lys05

Data Sheet For research use only. Not for human use.
Cat. No. :BCP20708CAS No. :1391426-24-6Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1391426-24-6 Cat. No. BCP20708
Name Lys05
Synonyms Lys01 trihydrochloride;Lys-01 trihydrochloride;Lys 01 trihydrochloride;LYS05; LYS-05;
SMILES CN(CCNC1=CC=NC2=C1C=CC(Cl)=C2)CCNC3=CC=NC4=CC(Cl)=CC=C43.[H]Cl.[H]Cl.[H]Cl
Chemical Name
Formula C23H26Cl5N5 M. Wt 549.75
Purity 98% Storage Store at 4-8°C
Description Lys05, or Lys01 trihydrochloride, is a potent, water soluble lysosomal autophagy inhibitor. Lys05 is a previously undescribed dimeric chloroquine which more potently accumulates in the lysosome and blocks autophagy compared with HCQ. Lys05 produced more potent antitumor activity as a single agent both in vitro and in vivo in multiple human cancer cell lines and xenograft models compared with HCQ. Lys05 is therefore a new lysosomal autophagy inhibitor that has potential to be developed further into a drug for cancer and other medical applications.
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