Mertansine New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP09450CAS No. ：139504-50-0Purity：98%

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CAS No.	139504-50-0	Cat. No.	BCP09450
Name	Mertansine
Synonyms	DM1; DM-1; DM 1; DM1 Compound; Maytansinoid DM 1; Maytansinoid DM1; Maytansinoid DM-1;
SMILES	C[C@@H]1[C@@H]2C[C@]([C@@H](/C=C\C=C(\CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)C[C@H]([C@]4(C1O4)C)OC(=O)[C@H](C)N(C)C(=O)CCS)C)/C)OC)(NC(=O)O2)O
Chemical Name
Formula	C35H48ClN3O10S	M. Wt	738.29
Purity	98%	Storage	Store at 4-8°C
Description	Mertansine refers to the thiol-containing maytansinoid, DM1 (N2’-deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through reaction of the thiol group with the SPP (N-succinimidyl 4-(2-pyridyldithio)) linker to create an antibody-drug conjugate or ADC. Experimental ADCs with the SPP-DM1 design include lorvotuzumab mertansine. DM1 can also be linked to an antibody using the SMCC (4-(3-mercapto-2,5-dioxo-1-pyrrolidinylmethyl)-cylohexanecarboxylic acid) linker, in which case the International Nonproprietary Name of the conjugate formed contains the word emtansine.