MS436
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1395084-25-9 | Cat. No. | BCP09947 |
| Name | MS436 | ||
| Synonyms | MS-436;MS 436; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C18H17N5O3S | M. Wt | 383.42 |
| Purity | Storage | Store at 4-8°C | |
| Description | MS436 exhibits low nanomolar affinity (estimated Ki of 30-50 nM), with preference for the first bromodomain over the second. MS436 effectively inhibits BRD4 activity in NF-κB-directed production of nitric oxide and proinflammatory cytokine interleukin-6 in murine macrophages. MS436 represents a new class of bromodomain inhibitors and will facilitate further investigation of the biological functions of the two bromodomains of BRD4 in gene expression. | ||
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