EPZ005687
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1396772-26-1 | Cat. No. | BCP07899 |
| Name | EPZ005687 | ||
| Synonyms | EPZ 005687; EPZ-005687; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C32H37N5O3 | M. Wt | 539.67 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | EZH2 is the catalytic subunit of the polycomb repressive complex 2 (PRC2) and is involved in repressing gene expression through methylation of histone H3 on lysine 27 (H3K27). EZH2 overexpression is implicated in tumorigenesis and correlates with poor prognosis in several tumour types. EPZ005687, a potent inhibitor of EZH2 (K(i) of 24 nM). EPZ005687 reduces H3K27 methylation in various lymphoma cells; this translates into apoptotic cell killing in heterozygous Tyr641 or Ala677 mutant cells, with | ||
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