ABT751
Data Sheet
For research use only. Not for human use.
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Publications Citing of Biochempartner's ABT751
| CAS No. | 141430-65-1 | Cat. No. | BCP02079 |
| Name | ABT751 | ||
| Synonyms | ABT 751;ABT-751;E 7010;E7010;E-7010; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C18H17N3O4S | M. Wt | 371.41 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | In this Calu-6 xenograft model, ABT-751 as a single agent at 100 and 75 mg/kg/day shows significant antitumor activity, while in combination with cisplatin, ABT-751 shows a dose-dependent enhancement in growth delay. In the HT-29 colon xenograft model, ABT-751 also shows significant antitumor activity as a single agent and produced a dose-dependent enhancement in growth delay In combination with 5-FU.In dogs with lymphoma, ABT-751 exhibits the dose-limiting toxicities that included vomiting, diarrhea, anorexia, or some combination of these with a maximum tolerated dose (MTD) of 350 mg/m2 PO q24h. Furthermore, the mean AUC and Cmax for ABT-751 at the MTD of 350 mg/m2 is 5.55 μg-hour/mL and 0.9 μg/mL, respectively. | ||
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