PF-543
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1415562-82-1 | Cat. No. | BCP07072 |
| Name | PF-543 | ||
| Synonyms | PF543; PF 543;Sphingosine Kinase 1 Inhibitor II; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C27H31NO4S | M. Wt | 465.6 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | PF-543 is a novel cell-permeant inhibitor of SphK1. PF-543 inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform. PF-543 is the most potent inhibitor of SphK1 described to date and it will be useful for dissecting specific roles of SphK1-driven S1P signalling. | ||
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