MM-102 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1417329-24-8 | Cat. No. | BCP11764 |
| Name | MM-102 | ||
| Synonyms | MM102;MM 102;HMTase Inhibitor IX; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C35H49F2N7O4 | M. Wt | 669.8 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | MM-102, as a MLL1 mimetic, shows high binding affinities to WDR5 with IC50 of 2.9 nM and Ki of < 1 nM. In the MLL1-AF9 transduced murine cells, MM-102 specifically reduces expression of two critical MLL1 target genes (HoxA9 and Meis-1), which are required for MLL1 mediated leukemogenesis. In addition, MM-102 effectively and selectively inhibits cell growth and induces apoptosis in leukemia cells harboring MLL1 fusion proteins. | ||
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