Acalabrutinib New
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| CAS No. | 1420477-60-6 | Cat. No. | BCP16312 |
| Name | Acalabrutinib | ||
| Synonyms | ACP-196;ACP196;ACP 196; | ||
| SMILES | CC#CC(=O)N1CCCC1C2=NC(=C3N2C=CN=C3N)C4=CC=C(C=C4)C(=O)NC5=CC=CC=N5 | ||
| Chemical Name | |||
| Formula | C26H23N7O2 | M. Wt | 465.19 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Acalabrutinib, also known as ACP-196, is an orally available inhibitor of Bruton’s tyrosine kinase (BTK) with potential antineoplastic activity. Upon administration, ACP-196 inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell activation and BTK-mediated activation of downstream survival pathways. This leads to an inhibition of the growth of malignant B cells that overexpress BTK. BTK, a member of the src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed in B-cell malignancies; it plays an important role in B lymphocyte development, activation, signaling, proliferation and survival. | ||
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